- Product Details
Keywords
- Rapamycin (Sirolimus)
- 53123-88-9
- 99% Rapamycin (Sirolimus)
Quick Details
- ProName: Rapamycin (Sirolimus)
- CasNo: 53123-88-9
- Molecular Formula: C51H79NO13
- Application: 53123-88-9
- DeliveryTime: in stock
- ProductionCapacity: 1kg Metric Ton/Day
- Purity: 99%
- LimitNum: 1 Gram
Superiority
In stock ,If you need HNMR\HPLC,please contact us!
Details
Rapamycin inhibits endogenous mTOR activity in HEK293 cells with IC50 of ~0.1 nM, more potently than iRap and AP21967 with IC50 of ~5 nM and ~10 nM, respectively. In Saccharomyces cerevisiae, Rapamycin treatment induces a severe G1/S cell cycle arrest and inhibition of translation initiation to levels below 20% of control. Rapamycin significantly inhibits the cell viability of T98G and U87-MG in a dose-dependent manner with IC50 of 2 nM and 1 μM, respectively, while displaying little activity against U373-MG cells with IC50 of >25 μM despite the similar extent of the inhibition of mTOR signaling. Rapamycin (100 nM) induces G1 arrest and autophagy but not apoptosis in Rapamycin-sensitive U87-MG and T98G cells by inhibiting the function of mTOR.