China (Mainland)
IWP-2 CAS NO.686770-61-6
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Keywords
- IWP-2
- 686770-61-6
- 98% IWP-2
Quick Details
- ProName: IWP-2
- CasNo: 686770-61-6
- Application: 686770-61-6
- DeliveryTime: in stock
- ProductionCapacity: 100g Metric Ton/Day
- Purity: 98%
- LimitNum: 1 Gram
Superiority
In stock ,If you need HNMR\HPLC,please contact us!
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Details
Inhibition of WNT signalling using FH535 and IWP-2 brought about a significant or borderline significant decrease in Caco-2(WISP2 KO) cell invasion (FH535 p=0.065) and (IWP-2 p=0.002) and negated the pro-invasive effect of targeting WISP2 in Caco-2 cells. IWP-2 decreased MKN28 cell proliferation, migration and invasion, and elevated caspase 3/7 activity. Further analysis demonstrated that IWP-2 downregulated the transcriptional activity of the Wnt/β-catenin signaling pathway and downregulated the expression levels of downstream Wnt/β-catenin target genes in MKN28 cells . Suppression of Wnt secretion from MSCs (IWP-2; 5 μmol/l) reduced the efficacy of ConT to induce phospho-LRP6 and to increase θ.