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Cjioo(Shanghai) biotechnology co., LTD(expird)

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Cjioo(Shanghai) biotechnology co., LTD(expird)

Business Type:Lab/Research institutions

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Year Established:
2015
Home>>Products>>Refametinib (RDEA119, Bay 86-9766)

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Cjioo(Shanghai) biotechnology co., LTD(expird)

Country: China (Mainland)

Business Type:Lab/Research institutions

Refametinib (RDEA119, Bay 86-9766)

CAS NO.923032-37-5

  • Min.Order: 1 Gram
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Keywords

  • Refametinib (RDEA119, Bay 86-9766)
  • 923032-37-5
  • 98% Refametinib (RDEA119, Bay 86-9766)

Quick Details

  • ProName: Refametinib (RDEA119, Bay 86-9766)
  • CasNo: 923032-37-5
  • Application: 923032-37-5
  • DeliveryTime: in stock
  • ProductionCapacity: 100g Metric Ton/Day
  • Purity: 98%
  • LimitNum: 1 Gram

Superiority

In stock ,If you need HNMR\HPLC,please contact us!

excellent quality and reasonable price and absolutely worthy.

Details

RDEA119 potently inhibited MEK activity in enzyme inhibition assays in a non-ATP-competitive manner (MEK1 IC50 = 19 nmol/L, MEK2 IC50 = 47 nmol/L) determined through incorporation of radioactive phosphate from ATP into ERK as substrate. RDEA119 potently inhibited MEK activity as measured by phosphorylation of ERK1/2 across several human cancer cell lines of different tissue origins and BRAF mutational status with EC50 values ranging from 2.5 to 15.8 nmol/L . BAY 86-9766 exhibited potent antiproliferative activity in HCC cell lines with half-maximal inhibitory concentration values ranging from 33 to 762 nM. BAY 86-9766 was strongly synergistic with sorafenib in suppressing tumor cell proliferation and inhibiting phosphorylation of the extracellular signal-regulated kinase (ERK) .

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