China (Mainland)
AMG 208 CAS NO.1002304-34-8
- Min.Order: 1 Gram
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- Product Details
Keywords
- AMG 208
- 1002304-34-8
- 99% AMG 208
Quick Details
- ProName: AMG 208
- CasNo: 1002304-34-8
- Application: 1002304-34-8
- DeliveryTime: in stock
- ProductionCapacity: 100g Metric Ton/Day
- Purity: 99%
- LimitNum: 1 Gram
Superiority
In stock ,If you need HNMR\HPLC,please contact us!
Details
AMG-208 shows the potent inhibition of kinase c-Met activity with IC50 of 9 nM in a cell-free assay. Besides, AMG-208 treatment also leads to the inhibition of HGF-mediated c-Met phosphorylation in PC3 cells with IC50 of 46 nM . Pre-incubation of AMG-208 with human liver microsomes for 30 minutes shows a potent time-dependent inhibition for CYP3A4 metabolic activity with IC50 of 4.1 μM, which is an eightfold decrease relative to the IC50 (32 μM) without preincubation . AMG-208 is identified to be a c-MET and RON dual selective inhibitor .