Welcome to LookChem.com Sign In|Join Free
The company logo of Cjioo(Shanghai) biotechnology co., LTD(expird)

Cjioo(Shanghai) biotechnology co., LTD(expird)

Free supplier

Free
supplier
10th
years

Cjioo(Shanghai) biotechnology co., LTD(expird)

Business Type:Lab/Research institutions

Main Products:
Year Established:
2015
Home>>Products>>NVP-BVU972

Product Certification&
Enterprise Certification

More Detail

Cjioo(Shanghai) biotechnology co., LTD(expird)

Country: China (Mainland)

Business Type:Lab/Research institutions

NVP-BVU972

CAS NO.1185763-69-2

  • Min.Order: 1 Gram
  • Payment Terms:
Contact Supplier

Product Details

Keywords

  • NVP-BVU972
  • 1185763-69-2
  • 99% NVP-BVU972

Quick Details

  • ProName: NVP-BVU972
  • CasNo: 1185763-69-2
  • Molecular Formula: C20H16N6
  • Application: 1185763-69-2
  • DeliveryTime: in stock
  • ProductionCapacity: 100g Metric Ton/Day
  • Purity: 99%
  • LimitNum: 1 Gram

Superiority

In stock ,If you need HNMR\HPLC,please contact us!

Details

NVP-BVU972 potently inhibits MET kinase but displays low inhibition against other kinases including the most closely related kinase RON with IC50 values of more than 1000 nM. NVP-BVU972 also suppresses constitutive MET phosphorylation in GTL-16 cells or HGF-stimulated MET phosphorylation in A549 cells with IC50 values of 7.3 nM and 22 nM, respectively. NVP-BVU972 potently prevents the growth of the MET gene amplified cell lines GTL-16, MKN-45 and EBC-1 with IC50 values of 66 nM, 82 nM and 32 nM, respectively. In line with their high frequency in the NVP-BVU972 screen, Y1230 and D1228 mutations give rise to dramatic shifts in the measured IC50 values for NVP-BVU972 in BaF3 cell line. Resistance triggered by V1155L is more limited to NVP-BVU972. A dose-dependent reduction in TPR-MET phosphorylation when applying NVP-BVU972 to BaF3 cells expressing wild-type TPR-MET. Both Y1230H and D1228A mutations abrogated the effect of NVP-BVU972 but not AMG 458. However, F1200I and L1195V interferes with the potency of NVP-BVU972 to prevent TPR-MET phosphorylation.

Hot Product