Welcome to LookChem.com Sign In|Join Free
The company logo of Cjioo(Shanghai) biotechnology co., LTD(expird)

Cjioo(Shanghai) biotechnology co., LTD(expird)

Free supplier

Free
supplier
10th
years

Cjioo(Shanghai) biotechnology co., LTD(expird)

Business Type:Lab/Research institutions

Main Products:
Year Established:
2015
Home>>Products>>CNX-2006

Product Certification&
Enterprise Certification

More Detail

Cjioo(Shanghai) biotechnology co., LTD(expird)

Country: China (Mainland)

Business Type:Lab/Research institutions

CNX-2006

CAS NO.1375465-09-0

  • Min.Order: 1 Gram
  • Payment Terms:
Contact Supplier

Product Details

Keywords

  • CNX-2006
  • 1375465-09-0
  • 99% CNX-2006

Quick Details

  • ProName: CNX-2006
  • CasNo: 1375465-09-0
  • Molecular Formula: C26H27F4N7O2
  • Application: 1375465-09-0
  • DeliveryTime: in stock
  • ProductionCapacity: 100g Metric Ton/Day
  • Purity: 99%
  • LimitNum: 1 Gram

Superiority

In stock ,If you need HNMR\HPLC,please contact us!

Details

CNX-2006 is a novel irreversible EGFR tyrosine kinase inhibitor, specifically inhibits activating mutations of EGFR as well as the T790M mutation while having very weak inhibition at wild-type EGFR. In in vitro modeling of acquired resistance, continuous CNX-2006 treatment on drug-sensitive EGFR mutant cells leads to resistance more slowly than erlotinib. Dose escalation with CNX-2006 leads to differential effects in different lines, but does not select for T790M-mediated resistance. CNX-2006 resistent cells shows increased expression of EMT markers and MMP9. CNX-2006 is effective in H1975 (EGFR L858R/T790M) xenograft model.

Hot Product