Keywords

• XMD17-109
• 1435488-37-1
• 98% XMD17-109

Quick Details

• ProName: ERK5-IN-1
• CasNo: 1435488-37-1
• Application: 1435488-37-1
• DeliveryTime: in stock
• ProductionCapacity: 100g Metric Ton/Day
• Purity: 98%
• LimitNum: 1 Gram

Superiority

In stock ,If you need HNMR\HPLC,please contact us!

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Details

The pAP1-luciferase reporter and pRL-CMV-Renilla plasmids were co-transfected with plasmids encoding for ERK5 and constitutively active MEK5 (MEK5DD) in HEK293 cells. Cells were treated with the indicated amounts of compound 26 (XMD17-109) for 24 h, and lysates were subjected to the dual-luciferase assay. Compound 26 completely inhibited the ERK5-mediated AP1 transcriptional activity at 30 μM and had an EC50 of 4.2 ± 0.7 μM. By contrast 24 had an EC50 of >30 μM[