Keywords

• Erlotinib HCl (OSI-744)
• 183319-69-9
• 99% Erlotinib HCl (OSI-744)

Quick Details

• ProName: Erlotinib HCl (OSI-744)
• CasNo: 183319-69-9
• Application: 183319-69-9
• ProductionCapacity: Metric Ton/Day
• Purity: 99%
• LimitNum: 0 Metric Ton

Superiority

In stock ,If you need HNMR\HPLC,please contact us!

Details

Erlotinib HCl potently inhibits EGFR activation in intact cells including HNS human head and neck tumor cells (IC50 20nM), DiFi humancolon cancer cells andMDA MB-468 human breast cancer cells. Erlotinib HCl (1 μM) induces apoptosis in DiFi humancolon cancer cells. Erlotinib inhibits growth of a panel of NSCLC cell lines including A549, H322, H3255, H358 H661, H1650, H1975, H1299, H596 with IC50 ranging from 29 nM to >20 μM. Erlotinib HCl(2 μM) significantly inhibits growth of AsPC-1 and BxPC-3 pancreatic cells. The effects of Erlotinib HCl in combination with gemcitabine are considered additive in KRAS-mutated pancreatic cancer cells. Ten micromolar of Erlotinib HCl inhibits EGFR phospho-rylation at the Y845 (Src-dependent phosphorylation) and Y1068 (auto-phosphorylation) sites.Combination with Erlotinib HCl could down-modulate rapamycin-stimulated Akt activity and produces a synergistic effect on cell growth inhibition.