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Cjioo(Shanghai) biotechnology co., LTD(expird)

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Cjioo(Shanghai) biotechnology co., LTD(expird)

Business Type:Lab/Research institutions

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Year Established:
2015
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Cjioo(Shanghai) biotechnology co., LTD(expird)

Country: China (Mainland)

Business Type:Lab/Research institutions

IWP-2

CAS NO.686770-61-6

  • Min.Order: 1 Gram
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Keywords

  • IWP-2
  • 686770-61-6
  • 98% IWP-2

Quick Details

  • ProName: IWP-2
  • CasNo: 686770-61-6
  • Application: 686770-61-6
  • DeliveryTime: in stock
  • ProductionCapacity: 100g Metric Ton/Day
  • Purity: 98%
  • LimitNum: 1 Gram

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In stock ,If you need HNMR\HPLC,please contact us!

excellent quality and reasonable price and absolutely worthy.

Details

Inhibition of WNT signalling using FH535 and IWP-2 brought about a significant or borderline significant decrease in Caco-2(WISP2 KO) cell invasion (FH535 p=0.065) and (IWP-2 p=0.002) and negated the pro-invasive effect of targeting WISP2 in Caco-2 cells. IWP-2 decreased MKN28 cell proliferation, migration and invasion, and elevated caspase 3/7 activity. Further analysis demonstrated that IWP-2 downregulated the transcriptional activity of the Wnt/β-catenin signaling pathway and downregulated the expression levels of downstream Wnt/β-catenin target genes in MKN28 cells . Suppression of Wnt secretion from MSCs (IWP-2; 5 μmol/l) reduced the efficacy of ConT to induce phospho-LRP6 and to increase θ.

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