Keywords

• VER-50589
• 747413-08-7
• 98% VER-50589

Quick Details

• ProName: VER-50589
• CasNo: 747413-08-7
• Application: 747413-08-7
• DeliveryTime: in stock
• ProductionCapacity: 100g Metric Ton/Day
• Purity: 98%
• LimitNum: 1 Gram

Superiority

In stock ,If you need HNMR\HPLC,please contact us!

excellent quality and reasonable price and absolutely worthy.

Details

VER-50589 produces a mean cellular antiproliferative GI50 value of 78 nM when tested against a human cancer cell line panel. Consistent with inhibition of Hsp90, VER-50589 induces the expression of HSP27 and Hsp72 while reducing the client proteins C-RAF, B-RAF, survivin, and PRMT5, causing cell cycle arrest and apoptosis. VER-50589 shows favorable pharmacokinetics and impairs tumor growth in animals. Importantly, glioblastoma cells do not acquire resistance to VER-50589 and resistance to other Hsp90 inhibitors does not produce cross-resistance to VER-50589.