- Product Details
Keywords
- A-769662
- 844499-71-4
- 99% A-769662
Quick Details
- ProName: A-769662
- CasNo: 844499-71-4
- Molecular Formula: C20H12N2O3S
- Application: 844499-71-4
- DeliveryTime: in stock
- ProductionCapacity: 100g Metric Ton/Day
- Purity: 99%
- LimitNum: 1 Gram
Superiority
In stock ,If you need HNMR\HPLC,please contact us!
Details
A-769662 stimulates partially purified rat liver AMPK with EC50 with 0.8 μM. A-769662 activates AMPK purified from multiple tissues and species in a dose-responsive manner with modest variations in observed EC50s. EC50s determined for A-769662 using partially purified AMPK extracts from rat heart, rat muscle, or human embryonic kidney cells (HEKs) are 2.2 mM, 1.9 mM, or 1.1 mM, respectively. A 4 hours treatment of primary rat hepatocytes with A-769662 dose-dependently increases ACC phosphorylation, which correlated inhibition of fatty acid synthesis with IC50 of 3.2 μM. A-769662 also inhibits fatty acid sythesis in mouse hepatocytes with IC50 with 3.6 μM . A-769662 activates AMPK both allosterically and by inhibiting dephosphorylation of AMPK on Thr-172, similar to the effects of AMP . A-769662 inhibits proteasomal function by an AMPK-independent mechanism. A-769662 affects the in vitro activity of purified 26S proteasomes but not the in vitro activity of purified 20S proteasomes. A-769662 has toxic effects on MEF cells .