China (Mainland)
Resminostat CAS NO.864814-88-0
- Min.Order: 1 Gram
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- Product Details
Keywords
- Resminostat(RAS2410; 4SC-201)
- 864814-88-0
- 98% Resminostat
Quick Details
- ProName: Resminostat
- CasNo: 864814-88-0
- Application: 864814-88-0
- DeliveryTime: in stock
- ProductionCapacity: 100g Metric Ton/Day
- Purity: 98%
- LimitNum: 1 Gram
Superiority
In stock ,If you need HNMR\HPLC,please contact us!
excellent quality and reasonable price and absolutely worthy.
Details
Resminostat strongly induced apoptosis (IC50=2.5-3 micromol/l in 3 out of 4 MM cell lines) in MM cell lines as well as primary MM cells. At 1micromol/l, resminostat inhibited proliferation and induced G0/G1 cell cycle arrest in 3 out of 4 MM cell lines accompanied with decreased levels of cyclin D1, cdc25a, Cdk4 and pRb as well as upregulation of p21. Resminostat decreased phosphorylation of 4E-BP1 and p70S6k indicating an interference with Akt pathway signalling. Treatment with resminostat resulted in increased protein levels of Bim and Bax and decreased levels of Bcl-xL. Caspases 3, 8 and 9 were activated by resminostat .